pKa相关论文
34. Effect and the Possible Mediated Pathway of Cortisol Secretion in Adrenocortical Cells Induced b
Objective: To understand the direct effect on the secretion of adreno-cortical cells induced by lead and cadmium and the......
研究两种芳香类中草药植物精油的抗抑郁功效及其作用机制.本文采用鼠尾悬挂和强迫游泳两种试验构建“行为绝望抑郁”模型,并测定模......
研究目的:牙种植术成功的关键在于种植体和骨之间建立稳定牢固的骨结合,药物可通过改变骨代谢影响这一结合。大量研究已经表明服用......
电压依赖性钾通道（KV）是钾通道超家族中成员最多,最为复杂的亚家族。在中枢神经系统中广泛分布。参与神经元生理和病理功能的精细调......
Spontaneously blinking probe, which switches between dark and bright state without UV or external additives, is extremel......
背景:周围神经损伤是一种主要由创伤等因素引起的临床常见疾病,研究表明,由骨髓间充质干细胞转分化的许旺细胞可以促进周围神经损......
背景骨骼肌随着年龄的增长及病理条件时会发生损耗和萎缩,但伴随这个过程,骨骼肌卫星细胞会以增殖、分化来实现生理条件下骨骼肌自......
目的:瞬时外向钾电流（Ito）在维持细胞膜电位和调节细胞兴奋性中起重要作用,Ito的异常是众多心肌兴奋性相关疾病的电生理基础。Kv4.2......
在真核细胞中,细胞核与细胞质之间蛋白质,RNA以及核糖体的转运是一项必需的生理活动。Importin β蛋白家族成员负责细胞内大多数蛋......
目的使用Cre/loxp重组酶系统构建的GABAA受体γ2亚基（GABRG2）基因条件敲除小鼠模型和使用CRISPR/Cas9技术构建的GABRG2基因条件性敲......
目的:通过观察和胃理气方对肝郁气滞型功能性消化不良（FD）模型大鼠一般状况、胃肠动力水平及胃组织环磷酸腺苷（c AMP）/蛋白激酶A（PKA）信......
目的:运用番泻叶泄泻、限制饮水、饥饱失常的复合方法,制备脾虚型便秘小鼠模型。将造模成功的小鼠用枳术汤干预治疗,对小鼠的排便......
发育阶段内的经历对于神经环路的形成以及维持大脑功能性的完整至关重要。在生命早期,尤其是大脑发育关键期,遭遇的一系列负性经历......
恐惧位于记忆和情感的交汇处,既是触发防御机制以适应危险的一种情绪反应,又是研究记忆的模型.恐惧调节障碍时常会导致焦虑.该文综......
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AlMg5 合金是NP 反应堆上冷源堆内核心部件(冷包)的制造材料，由于冷包安装位置靠近堆芯，受冷源装置工作环境需求，该AlMg5 合金材料长......
目的 胶质瘤中G 蛋白亚基13(GNA13)表达与患者不良预后呈负相关，是胶质瘤重要功能基因。本文拟通过生物信息学分析探讨胶质瘤中GNA1......
Objective: It is now widely accepted that mitochondrial calcium homeostasis and mitochondrial biogenesis plays a series ......
The disturbance of hippocampal CaMKII/PKA/PKC phosphorylation in early experimental diabetes mellitu
Aim: To studyhowhippocampalserine/threonine kinases signaling changes inthe early phase of diabetic rats (both type 1 an......
Objective It has been shown that sigma-1 receptor modulated many biological function and play an important role in neuro......
Atorvastatin has been shown to affect cognitive functions in rodents and humans.However,the underlying mechanism is not ......
Aim-To investigate the miRNA profile in the corpus cavernosum (CC) of aging rats with ED.Methods-The experimental animal......
Long-term potentiation(LTP)is the key cellular mechanism for physiological learning and pathological chronic pain.Postsy......
The large conductance voltage-and Ca-activated K(BK) channel is a critical regulator of urinary bladder smooth muscle (U......
Imbalance of HCN1/2 Surface Expression was Involved in Hippocampal CA1 Area in Chronic Morphine Expo
Aim: Our previous study has found that the imbalance of HCN1/2 surface expression is observed in hippocampal CA1 area in......
Inhibition of LTP by β-amyloid is prevented by activation of β2 adrenoceotors and stimulation of cAM
The present study investigated the role of β-adrenoceptors and the downstream cAMP/PKA signaling pathway on the A β in......
目的：通过研究耳聋左慈丸对老年性耳聋小鼠耳蜗组织cAMP、PKA表达的影响，探讨老年性耳聋的治疗机制。方法：选取75只耳廓反应灵敏的雄......
主流抗抑郁西药具有起效缓慢的缺点，目前研究较多的快速抗抑郁药物氯胺酮因成瘾性、肝毒性和神经毒性等副作用在临床应用中受到限制......
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In this article,the protonation processes before and after decarboxylation of oro tidine 5 -monophosphate(OMP)catalyzed ......
对化合物pKa的研究不仅有助于考察复杂样品中组分的物理化学性质 [1,2].根据化合物的结构,能够推测其pKa 值;反之亦然,通过化合物......
Promotion of PDGF-induced endothelial cell migration by phosphorylated VASP depends on PKA anchoring
Vasodilator-stimulated phosphoprotein (VASP), an important substrate of PKA, plays a critical role in VASP remodeling of......
乳腺癌是女性中发病率最高的恶性肿瘤之一，临床主要通过静脉使用化疗药物-紫杉醇对其进行治疗。然而，由于紫杉醇自身溶解性差且具有......
Glucagon-like peptide 1 stimulates insulin secretion via inhibiting RhoAROCK signaling and disassemb
Aims/hypothesis chronic hyperglycemia results in impaired glucose-stimulated insulin secretion (GSIS).Glucagon-Like ......
Phosphorylation of Serine 158 in Proteasome 1 Subunit Regulates Its Conversion From Proteasomal Asse
p27kip1 is one of the key factors controlling cell cycle.The intracellular level of p27kip1 is mainly regulated by the u......
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急性白血病和弥漫性血管内凝血血浆ＰＫ和ＰＫＡ含量及其意义杨艳敏，吕筱华，高鹏远，韩乃英（第二临床学院血液内科）关键词急性白血病；弥漫性血管内凝......
目的：静脉麻醉药异丙酚在临床麻醉过程中对循环抑制的机制尚不明确，既往研究表明异丙酚对心脏有直接抑制作用，本研究旨在明确异丙......
目的 探讨电针能否促进帕金森病(PD)模型小鼠黑质致密部蛋白激酶A(PKA)、cAMP反应元件结合蛋白1(CREB1)的表达.方法 以腹腔注射(30......
目的 通过体外磷酸化研究和放射自显影技术证实小鼠CDC25B蛋白是蛋白激酶A(PKA)的直接作用底物.方法 构建小鼠截短型pGEx-4T-2-CDC......
骨骼肌纤维类型的转化涉及复杂的分子机制。研究表明缺氧诱导因子(HIF)-2α可诱导肌纤维类型向慢肌型转化,但其下游途径尚未阐明。......
